Commercial OpportunityZerlasiran's ~100% Lp(a) reduction in clinic, coupled with low dosing frequency and clean safety profile can render a significant commercial opportunity.
Financial FlexibilitySilence's cash runway now extends into 2027, providing financial flexibility to advance its RNAi pipeline in rare diseases.
Regulatory ValidationZerlasiran represents a potential blockbuster opportunity, particularly with regulatory validation from the FDA (U.S.), EMA (Europe), and PMDA (Japan) on the pivotal trial design.