Market ChallengesAmvuttra is either not covered or 'effectively' not covered in several Medicare segments, disadvantaged in MAPD & non-Medicare, and advantaged in Medigap-related segments.
Product Development IssuesDevelopment of ALN-KHK, an RNAi therapeutic targeting ketohexokinase for type 2 diabetes, has been suspended.
Regulatory ConcernsAn advisory committee meeting is not planned, a concern due to ALNY's recent track record with the Agency and last-minute changes.