Clinical DevelopmentManagement downplayed the translatability of biomarker data from an ongoing RAGE study, deciding to move to Ph2a without waiting for this data.
Financial PerformanceKey value drivers are seen as emerging likely starting in 2026, thus awaiting validation of those opportunities to understand the longer-term growth profile of the company.
Product PerformancePlozasiran treatment led to a rise in LDL cholesterol, which is not a desired treatment outcome even if TGs decrease.