Clinical Trial SetbacksSimufilam failed to show a significant reduction in cognitive or functional decline versus placebo in mild-to-moderate Alzheimer’s disease patients.
Stock Rating DowngradeAnalyst downgrades the stock rating to Neutral from Buy, removing forecasts for simufilam approval and related revenues.
Trial FailureTop-line results from ReThink-ALZ, a Phase 3 clinical trial with simufilam in patients with mild-to-moderate Alzheimer's disease, did not meet the study’s pre-specified co-primary, secondary, and exploratory biomarker endpoints, leading to the trial's termination.