Clinical Trial TerminationAll remaining clinical studies involving masofaniten, including those combining it with abiraterone acetate and apalutamide and other investigator-sponsored trials, will be discontinued.
Drug Development DiscontinuationEPIX announced that it will discontinue all masofaniten development following a pre-specified futility analysis that showed that this candidate failed to meet the target efficacy profile in the Phase 2 enzalutamide combo study in mCRPC patients naïve to second-generation antiandrogens.
Efficacy AnalysisThe futility analysis revealed that the enzalutamide monotherapy control arm was performing better than historical controls and similar to the masofaniten + enzalutamide combo.