Clinical TrialsInvestors are reminded of the prior late-stage failures for tarcocimab in the Phase 3 GLEAM and GLIMMER trials in DME, unexpected increase in cataract AEs over time for tarcocimab, and the Phase 2b/3 DAZZLE trial failure in wet AMD.
Market CompetitionThe retinal disease landscape continues to evolve with many differentiated approaches creating further headwinds for ABCD conjugate positioning.
Product FormulationThe former tarcocimab formulation had a detrimental gel-like formulation that required extended delivery time and force, with potential lens mechanical insult.