Commercial ChallengesRisks include commercial challenges with Cabometyx, potential failure to generate favorable clinical data, and possible generic erosion.
Market UncertaintyThere is a lack of clarity surrounding the size of the market opportunity in neuroendocrine tumors, which has generated debate even though there is significant unmet need in the space.
Safety ConcernsIn the pNET cohort 46% of patients receiving cabo had a serious adverse event, with 49% dose reduction and 19% permanently discontinued cabo due to an adverse event.