Strong Performance of Cabozantinib Franchise
The cabozantinib business saw an approximate 11% growth in demand, new starts, and revenue. Fourth quarter U.S. cabo franchise net product revenues grew 20% year-over-year to $515 million, while full year 2024 U.S. cabo franchise net product revenues grew 11% to $1.81 billion.
Regulatory Progress for Cabozantinib
The FDA accepted the sNDA for cabozantinib in pNET and epNET indications with a PDUFA date of April 3, 2025. Detailed final results from the CABINET Phase III pivotal trial were published in the New England Journal of Medicine.
Pipeline Growth and New Trials
Exelixis plans to accelerate the Phase I development of XL309 and file up to three new INDs for XB628, XB064, and XB371 in 2025, with significant data presentations expected at major scientific meetings.
Strong Financial Position
The company reported a GAAP net income of approximately $139.9 million for the fourth quarter and repurchased approximately $656 million of the company's shares in 2024.