Clinical DataPositive 72-week data from the Phase IIb ORIGIN study in IgA nephropathy (IgAN) show sustained reductions in Gd-IgA1 and proteinuria, along with eGFR stabilization.
Market OpportunityVertex's acquisition of Alpine for approximately $4.9 billion in cash underscores the significant commercial potential of BLyS/APRIL inhibitors.
Safety ProfileBoth doses of the treatment have been generally well-tolerated with no severe infections or significant adverse effects reported, pointing to a favorable safety profile.