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Third Harmonic Bio, Inc. (THRD)
NASDAQ:THRD
US Market

Third Harmonic Bio, Inc. (THRD) AI Stock Analysis

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Third Harmonic Bio, Inc.

(NASDAQ:THRD)

43Neutral
Third Harmonic Bio, Inc.'s overall stock score reflects a combination of strong financial stability due to high equity and low debt, countered by significant operational challenges, including lack of revenue and reliance on financing. The technical analysis indicates a bearish trend, and the recent restructuring plan adds to the uncertainty about the company's operational effectiveness and future growth prospects.
Positive Factors
Financial Stability
Third Harmonic ended the fourth quarter of 2024 with $285 million in cash, which is expected to support operations at least through 2026.
Research and Development
THB335 demonstrated strong pharmacokinetics and pharmacodynamics with deep serum tryptase reductions.
Negative Factors
Safety Concerns
Safety concerns from Phase 1 data, including reductions in hemoglobin and neutrophils, likely limit the use of higher doses of THB335.
Stock Downgrade
The stock rating for THRD has been downgraded to Hold due to a lack of clarity on the development path for THB335.
Strategic Uncertainty
There is uncertainty regarding the future development of THB335 and the company's strategic direction.

Third Harmonic Bio, Inc. (THRD) vs. S&P 500 (SPY)

Third Harmonic Bio, Inc. Business Overview & Revenue Model

Company DescriptionThird Harmonic Bio, Inc. (THRD) is a biopharmaceutical company focused on the discovery and development of innovative therapies for the treatment of allergic and inflammatory diseases. Leveraging its expertise in immunology and drug development, the company aims to address unmet medical needs by creating targeted therapies that modulate specific pathways involved in allergic and inflammatory responses.
How the Company Makes MoneyThird Harmonic Bio, Inc. generates revenue primarily through the development and commercialization of its proprietary drug candidates. The company may engage in collaborations and partnerships with other pharmaceutical firms to co-develop or license its therapies, which can provide milestone payments and royalties based on sales. Additionally, the company might receive funding through grants or research collaborations with academic institutions and government entities. Revenue is typically reinvested into research and development to advance its drug pipeline and bring new treatments to market.

Third Harmonic Bio, Inc. Financial Statement Overview

Summary
Third Harmonic Bio, Inc. shows strong financial stability with high equity and low debt, scoring 75 on the balance sheet. However, the lack of revenue results in a low income statement score of 20, and cash flow challenges are reflected in a score of 30. The company relies heavily on financing rather than operational revenue, which is a concern for long-term sustainability.
Income Statement
20
Very Negative
The company has consistently reported zero revenue over the years, indicating no operational income. The net income improved from a negative position to a positive $45.5 million in 2024, primarily due to cost management or financing activities rather than operational growth.
Balance Sheet
75
Positive
The company has a robust equity position with $285 million in stockholders' equity in 2024, and a low debt level with a debt-to-equity ratio of 0.011. The equity ratio is very high, indicating strong financial stability. However, the reliance on equity over operational revenue could be a potential risk.
Cash Flow
30
Negative
Operating cash flow remains negative, highlighting operational challenges. However, free cash flow improved significantly in 2024, driven by financing activities. The company relies heavily on financing to sustain operations, which may not be sustainable in the long term.
Breakdown
Dec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income StatementTotal Revenue
0.000.000.000.000.00
Gross Profit
0.00-35.00K-38.00K0.000.00
EBIT
58.87M-43.95M-37.71M-19.00M-11.12M
EBITDA
58.87M-30.79M-35.12M-10.61M-1.69M
Net Income Common Stockholders
45.47M-30.82M-37.71M-29.61M-12.81M
Balance SheetCash, Cash Equivalents and Short-Term Investments
285.06M269.07M288.88M128.28M8.28M
Total Assets
294.61M277.71M298.68M129.16M8.43M
Total Debt
3.21M3.95M4.34M0.000.00
Net Debt
-281.86M-265.12M-284.54M-128.28M-8.28M
Total Liabilities
9.46M8.63M9.61M175.87M26.79M
Stockholders Equity
285.15M269.08M289.07M-46.71M-18.36M
Cash FlowFree Cash Flow
-34.51M-20.59M-34.95M-15.75M-9.19M
Operating Cash Flow
-34.50M-20.43M-34.92M-15.75M-9.19M
Investing Cash Flow
-10.00K-169.00K-36.00K0.000.00
Financing Cash Flow
50.51M799.00K195.99M135.75M10.82M

Third Harmonic Bio, Inc. Technical Analysis

Technical Analysis Sentiment
Neutral
Last Price3.36
Price Trends
50DMA
3.97
Negative
100DMA
7.55
Negative
200DMA
10.08
Negative
Market Momentum
MACD
-0.21
Negative
RSI
35.93
Neutral
STOCH
38.25
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For THRD, the sentiment is Neutral. The current price of 3.36 is below the 20-day moving average (MA) of 3.50, below the 50-day MA of 3.97, and below the 200-day MA of 10.08, indicating a neutral trend. The MACD of -0.21 indicates Negative momentum. The RSI at 35.93 is Neutral, neither overbought nor oversold. The STOCH value of 38.25 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Neutral sentiment for THRD.

Third Harmonic Bio, Inc. Risk Analysis

Third Harmonic Bio, Inc. disclosed 68 risk factors in its most recent earnings report. Third Harmonic Bio, Inc. reported the most risks in the “Tech & Innovation” category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Third Harmonic Bio, Inc. Peers Comparison

Overall Rating
UnderperformOutperform
Sector (48)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
60
Neutral
$3.08B-39.22%-31.37%
48
Neutral
$6.86B1.11-50.22%2.47%16.71%1.53%
43
Neutral
$156.51M-16.41%-14.76%
43
Neutral
$2.90B-74.17%-43.10%
38
Underperform
$33.26M-88.91%30.37%
29
Underperform
$68.74M-155.76%25.77%32.56%
28
Underperform
$67.69M-59.64%-40.59%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
THRD
Third Harmonic Bio, Inc.
3.55
-5.76
-61.87%
AKRO
Akero Therapeutics
41.95
18.77
80.97%
IGMS
IGM Biosciences
1.23
-7.80
-86.38%
CABA
Cabaletta Bio
1.24
-15.20
-92.46%
IMVT
Immunovant
16.42
-14.76
-47.34%
ALXO
ALX Oncology Holdings
0.60
-10.20
-94.44%

Third Harmonic Bio, Inc. Corporate Events

Product-Related AnnouncementsBusiness Operations and Strategy
Third Harmonic Bio Advances THB335 for Inflammatory Diseases
Neutral
Mar 11, 2025

Third Harmonic Bio, Inc. has released a corporate presentation detailing their focus on advancing THB335, a novel treatment for mast cell-mediated inflammatory diseases. The presentation highlights the potential of THB335 to address unmet needs in conditions like chronic spontaneous urticaria, emphasizing its efficacy and convenience over existing treatments. The company is in the early stages of development, with THB335 showing promise in Phase 1 trials, but faces risks typical of early-stage biotech firms, including the need for additional funding and regulatory hurdles.

Business Operations and Strategy
Third Harmonic Bio, Inc. Announces Restructuring Plan
Negative
Feb 11, 2025

On February 11, 2025, Third Harmonic Bio, Inc. announced a restructuring plan aimed at reducing operating costs and aligning its workforce with its strategic research and development goals. This plan involves reducing the workforce by approximately 27 employees, or 50%, with severance benefits contingent upon acceptance of a severance agreement, and is expected to incur around $2.3 million in severance and exit costs. After these restructuring costs and other expenses, the company expects to have cash and equivalents of $262 million to $267 million by June 30, 2025.

Glossary
OutperformA stock rated as "Outperform" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests that the stock is likely to deliver higher returns compared to the average returns of other stocks in the same sector or market index. Investors might consider this stock a good buying opportunity.
NeutralA stock rated as "Neutral" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly attractive nor unattractive for investment. Investors may consider holding onto the stock, as it is not expected to either significantly outperform or underperform the market.
UnderperformA stock rated as "Underperform" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests that the stock may deliver lower returns compared to the average returns of other stocks in the same sector or market index. Investors might consider selling the stock or avoiding it as an investment.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.