Clinical TrialsThe bar for Pfizer's mevrometostat is considered to be a hazard ratio of less than 0.70 and showing a progression-free survival benefit of more than 30% with mevrometostat + Xtandi over Xtandi alone.
Market CompetitionThere are clear signs of differentiation in ORIC's development plan with specificity, breadth of mutation coverage, and safety profile in a crowded EGFR/HER2 space in NSCLC.
Regulatory ChallengesPotential accelerated approval for ORIC-114 in non-small cell lung cancer could be on the horizon, based on broad activity data expected in the upcoming clinical updates.