Clinical ChallengesDurable responses were only seen in melanoma patients, with no responses in CRC and PDAC patients, leading to a shift away from a tissue-agnostic approach.
Development TimelineIt will take time for clinical data to be generated for ERAS-0015 and ERAS-4001.
Efficacy LimitationsEfficacy in non-melanoma tumor types was limited, with a 23% response rate, which was anticipated given the complex MAPK feedback across different tissue types.