Clinical ResponseDurable responses were only seen in melanoma patients, with no responses in CRC and PDAC patients, leading to the discontinuation of a tissue-agnostic approach.
EfficacyEfficacy in non-melanoma tumor types was limited, with a 23% response rate, which was anticipated given the complex MAPK feedback across different tissue types.
Strategic ShiftThe data did not support the company's 30-40% response rate threshold to pursue a tissue-agnostic approach.