Clinical EfficacyThe overall response rate in target lung lesions specifically was 36%, with three partial responses and one complete response, and disease control rate of 82%.
Clinical Safety And TolerabilityThe safety profile of ‘707 in the NSCLC population is strong, with most adverse events being mild to moderate and no grade 4+ adverse events recorded.
Platform PotentialInitial KB707 data supports the safe readministration of Krystal’s inhaled HSV-1 genetic platform, which has positive implications for KB408 in AATD and KB407 in cystic fibrosis.