Completion of Phase III SENTRY Trial Enrollment
Karyopharm completed enrollment in the Phase III SENTRY trial for frontline myelofibrosis, marking a pivotal moment for the company with top-line results expected in March 2026.
Strengthened Financial Flexibility
Karyopharm secured approximately $100 million through refinancing and capital restructuring, extending their cash runway into the second quarter of 2026.
Revenue Growth
Total revenue for Q3 2025 was $44 million, an increase of 13.4% compared to Q3 2024. U.S. net product revenue for XPOVIO grew 8.5% year-over-year.
Cost Reduction Achievements
Research and development expenses decreased by 16%, and selling, general, and administrative expenses decreased by 4% compared to Q3 2024.
High Physician Intent for Combination Therapy
75% of U.S. physicians showed intent to treat with selinexor plus ruxolitinib combination therapy for myelofibrosis, indicating strong market potential.