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Karyopharm Therapeutics (KPTI)
NASDAQ:KPTI
US Market
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Karyopharm Therapeutics (KPTI) Earnings Dates, Call Summary & Reports

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Earnings Data

Report Date
Feb 12, 2026
TBA (Confirmed)
Period Ending
2025 (Q4)
Consensus EPS Forecast
-1.97
Last Year’s EPS
-3.6
Same Quarter Last Year
Based on 6 Analysts Ratings

Earnings Call Summary

Q3 2025
Earnings Call Date:Nov 03, 2025|
% Change Since:
|
Earnings Call Sentiment|Positive
The earnings call highlighted significant progress in clinical trials and financial fortification, along with positive revenue growth and cost management. However, the net loss and the challenge of innovating within a stagnant market were concerns.
Company Guidance
During the Karyopharm Therapeutics Q3 2025 Earnings Call, significant guidance was provided on both the company's clinical and financial trajectory. Key clinical progress included the completion of enrollment in the Phase III SENTRY trial for frontline myelofibrosis, with top-line results anticipated in March 2026. Financially, the company bolstered its position by securing $100 million, extending its cash runway into Q2 2026. Karyopharm reported Q3 total revenue of $44 million, a 13% year-over-year increase, with U.S. net product revenue from XPOVIO growing 8.5% to $32 million. The company's R&D and SG&A expenses were $30.5 million and $26.6 million, respectively, reflecting disciplined cost management. Karyopharm also narrowed its 2025 expense guidance range to $235-$245 million, down from $240-$250 million.
Completion of Phase III SENTRY Trial Enrollment
Karyopharm completed enrollment in the Phase III SENTRY trial for frontline myelofibrosis, marking a pivotal moment for the company with top-line results expected in March 2026.
Strengthened Financial Flexibility
Karyopharm secured approximately $100 million through refinancing and capital restructuring, extending their cash runway into the second quarter of 2026.
Revenue Growth
Total revenue for Q3 2025 was $44 million, an increase of 13.4% compared to Q3 2024. U.S. net product revenue for XPOVIO grew 8.5% year-over-year.
Cost Reduction Achievements
Research and development expenses decreased by 16%, and selling, general, and administrative expenses decreased by 4% compared to Q3 2024.
High Physician Intent for Combination Therapy
75% of U.S. physicians showed intent to treat with selinexor plus ruxolitinib combination therapy for myelofibrosis, indicating strong market potential.

Karyopharm Therapeutics (KPTI) Earnings, Revenues Date & History

The upcoming earnings date is based on a company’s previous reporting, and may be updated when the actual date is announced

KPTI Earnings History

Report Date
Fiscal Quarter
Forecast / EPS
Last Year's EPS
EPS YoY Change
Press Release
Slides
Play Transcript
Feb 12, 2026
2025 (Q4)
-1.97 / -
-3.6
Nov 03, 2025
2025 (Q3)
-3.47 / -3.82
-3.92.05% (+0.08)
Aug 11, 2025
2025 (Q2)
-4.08 / -4.32
-3-44.00% (-1.32)
May 12, 2025
2025 (Q1)
-4.42 / -2.77
-4.842.29% (+2.03)
Feb 19, 2025
2024 (Q4)
-3.92 / -3.60
-5.433.33% (+1.80)
Nov 05, 2024
2024 (Q3)
-3.94 / -3.90
-4.513.33% (+0.60)
Aug 06, 2024
2024 (Q2)
-4.47 / -3.00
-4.3531.03% (+1.35)
May 08, 2024
2024 (Q1)
-5.01 / -4.80
-4.5-6.67% (-0.30)
Feb 29, 2024
2023 (Q4)
-4.65 / -5.40
-6.4516.28% (+1.05)
Nov 02, 2023
2023 (Q3)
-4.20 / -4.50
-6.7533.33% (+2.25)
The table shows recent earnings report dates and whether the forecast was beat or missed. See the change in forecast and EPS from the previous year.
Beat
Missed

KPTI Earnings-Related Price Changes

Report Date
Price 1 Day Before
Price 1 Day After
Percentage Change
Nov 03, 2025
$5.80$6.07+4.66%
Aug 11, 2025
$3.94$3.77-4.31%
May 12, 2025
$6.15$4.92-20.00%
Feb 19, 2025
$9.45$9.00-4.76%
Earnings announcements can affect a stock’s price. This table shows the stock's price the day before and the day after recent earnings reports, including the percentage change.

FAQ

When does Karyopharm Therapeutics (KPTI) report earnings?
Karyopharm Therapeutics (KPTI) is schdueled to report earning on Feb 12, 2026, TBA (Confirmed).
    What is Karyopharm Therapeutics (KPTI) earnings time?
    Karyopharm Therapeutics (KPTI) earnings time is at Feb 12, 2026, TBA (Confirmed).
      Where can I see when companies are reporting earnings?
      You can see which companies are reporting today on our designated earnings calendar.
        What companies are reporting earnings today?
        You can see a list of the companies which are reporting today on TipRanks earnings calendar.
          What is KPTI EPS forecast?
          KPTI EPS forecast for the fiscal quarter 2025 (Q4) is -1.97.
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