Market CompetitionPotential emerging competition from novel kappa opioid receptor antagonists being developed by Neumora Therapeutics and Johnson & Johnson.
Pipeline Execution RiskIf ADVANCE-2 fails, the stock could decline significantly, raising doubts about AXSM's ability to execute on its pipeline.
Prescription PerformanceWeekly prescription data for Auvelity showed no growth in TRx and NRx, indicating flat performance.