Strong Cash Position and Financial Health
Fulcrum ended 2024 with cash, cash equivalents, and marketable securities of $241 million, an increase from $236.2 million as of December 31, 2023, due to an $80 million upfront payment from Sanofi. This positions the company to fund operations into 2027.
Significant Reduction in Net Loss
The net loss for the year ended December 31, 2024, was $9.7 million, a substantial decrease from $97.3 million for the same period in 2023, indicating improved financial management and reduced expenses.
Progress in Sickle Cell Disease Program
The PIONEER trial for pociredir, an oral HbF inducer for sickle cell disease, shows promising progress with enrollment continuing and data from the 12 mg cohort expected mid-2025.
Reduction in Operating Expenses
Research and development expenses decreased by $8.4 million and general and administrative expenses decreased by $5.3 million in 2024 compared to 2023, primarily due to workforce reduction and cost-sharing reimbursements.