Drug Side EffectsBlueprint's avapritinib has shown higher rates of periorbital edema and cognitive side effects in ASM, with rates ranging from 48% to 55% and 11% to 25% respectively.
Market CompetitionThe competitive landscape includes several companies developing similar therapies, which could impact Blueprint Medicines' market position.
Patient GrowthThe new patient iSM adds were down 58% from the 189 new patients estimated in 2Q to 81 new patients in 3Q, suggesting a significant slowdown.