Clinical EfficacyThe median progression-free survival for 3L+ PDAC falls into the lower end of the expected range, potentially underestimating the survival benefit.
Regulatory And Market RisksRisks include clinical setbacks with RMC-4630, inability to secure timely regulatory approval, poorer-than-anticipated sales performance, failures with other pipeline candidates, and possible long-term dilution risk.
Side EffectsEmerging side effect issues such as large intestine perforation could impact progression-free survival.