AYVAKIT Revenue Growth
In 2024, AYVAKIT achieved $479 million in product revenue, representing impressive annual growth of 135%. The company expects AYVAKIT to achieve $680 million to $710 million in revenue in 2025, with a projected 45% growth rate at the midpoint.
Increased Market Opportunity
Blueprint Medicines identified a larger SM market than previously thought, with new epidemiology data suggesting a twofold increase in potential SM patients in the U.S., from approximately 30,000 to 60,000 patients.
International Expansion
The company obtained ISM pricing for AYVAKIT in Germany and plans to launch in additional European markets, with significant international revenue growth expected.
BLU-808 Clinical Development
Positive healthy volunteer data for BLU-808 showing a wide therapeutic index and promising pharmacodynamics, with proof-of-concept studies planned for multiple allergic and inflammatory diseases.
Financial Discipline
Blueprint Medicines reported a significant reduction in cash burn, with operating expenses reduced in 2024 compared to 2023, and expects operating cash burn to continue to decline in 2025.