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BioMarin Pharmaceutical (BMRN)
NASDAQ:BMRN

BioMarin Pharmaceutical (BMRN) AI Stock Analysis

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BioMarin Pharmaceutical

(NASDAQ:BMRN)

77Outperform
BioMarin Pharmaceutical is well-positioned with strong financial performance, highlighted by robust revenue and profit growth, and a solid balance sheet. Technical analysis suggests caution with bearish indicators, but valuation remains reasonable given growth expectations. The positive sentiment from the earnings call supports the company's strategic positioning and operational strength. Challenges include managing VOXZOGO's revenue dynamics and tariff exposure, but overall, the outlook remains optimistic.
Positive Factors
Drug Development
The Phase III PEGASUS trial of Palynziq in adolescents with phenylketonuria met its primary endpoint, demonstrating a significant lowering in blood Phe levels compared to diet alone.
Earnings
BioMarin's first quarter revenue of $745 million, a year-over-year increase of 15%, beat both the estimate of $735.6 million and consensus of $738.1 million.
Sales Growth
Voxzogo's growth continues to be strong with a 40% year-over-year increase.
Negative Factors
Market Competition
Emerging therapies with competitive risk/benefit profiles, such as PTC’s sepiapterin, could pose a competitive threat to Palynziq in the market.
Revenue Variability
There was a modest quarter-over-quarter revenue decline due to the complexity of market dynamics and the variability of ex-U.S. government orders.
Safety Concerns
There is uncertainty about safety results due to the existing black-box warning for Palynziq, which could affect investor perception.

BioMarin Pharmaceutical (BMRN) vs. S&P 500 (SPY)

BioMarin Pharmaceutical Business Overview & Revenue Model

Company DescriptionBioMarin Pharmaceutical Inc. develops and commercializes therapies for people with serious and life-threatening rare diseases and medical conditions. Its commercial products include Vimizim, an enzyme replacement therapy for the treatment of mucopolysaccharidosis (MPS) IV type A, a lysosomal storage disorder; Naglazyme, a recombinant form of N-acetylgalactosamine 4-sulfatase for patients with MPS VI; and Kuvan, a proprietary synthetic oral form of 6R-BH4 that is used to treat patients with phenylketonuria (PKU), an inherited metabolic disease. The company's commercial products also comprise Palynziq, a PEGylated recombinant phenylalanine ammonia lyase enzyme, which is delivered through subcutaneous injection to reduce blood Phe concentrations; Brineura, a recombinant human tripeptidyl peptidase 1 for the treatment of patients with ceroid lipofuscinosis type 2, a form of Batten disease; Voxzogo, a once daily injection analog of c-type natriuretic peptide for the treatment of achondroplasia; and Aldurazyme, a purified protein designed to be identical to a naturally occurring form of the human enzyme alpha-L-iduronidase. In addition, it develops valoctocogene roxaparvovec, an adeno associated virus vector, which is in Phase III clinical trial for the treatment of patients with severe hemophilia A; BMN 307, an AAV5 mediated gene therapy, which is in Phase 1/2 clinical trial to normalize blood Phe concentration levels in patients with PKU; and BMN 255 that is in Phase 1/2 clinical trial for treating primary hyperoxaluria. The company serves specialty pharmacies, hospitals, and non-U.S. government agencies, as well as distributors and pharmaceutical wholesalers in the United States, Europe, Latin America, and internationally. BioMarin Pharmaceutical Inc. has license and collaboration agreements with Sarepta Therapeutics, Ares Trading S.A., Catalyst Pharmaceutical Partners, Inc., and Asubio Pharma Co., Ltd. The company was incorporated in 1996 and is headquartered in San Rafael, California.
How the Company Makes MoneyBioMarin Pharmaceutical generates revenue through the development, production, and sales of its pharmaceutical products. The company's primary revenue streams come from the commercial sales of its approved therapies, such as Kuvan and Palynziq for PKU and Vimizim for MPS IV. BioMarin also earns money through collaborations and licensing agreements with other pharmaceutical companies, leveraging its proprietary research and development capabilities. Additionally, the company may receive milestone payments and royalties from partnered products. Key factors contributing to its earnings include successful product launches, regulatory approvals, and the expansion of its product pipeline addressing rare and underserved medical conditions.

BioMarin Pharmaceutical Key Performance Indicators (KPIs)

Any
Any
Revenue by Segment
Revenue by Segment
Analyzes income from different business units, highlighting which segments drive growth and profitability, and indicating areas of strategic focus or potential vulnerability.
Chart InsightsBioMarin's revenue growth is driven by VOXZOGO, which surged 40% year-over-year, and PALYNZIQ, up 22%. This aligns with a strategic focus on expanding global presence and innovation. Despite consistent quarterly revenues for VOXZOGO due to global order dynamics, the company projects significant growth in the latter half of 2025. The earnings call highlights robust financial performance and a strategic transformation, positioning BioMarin well against market uncertainties, with two-thirds of revenue sourced internationally, providing a buffer against US-specific economic conditions.
Data provided by:Main Street Data

BioMarin Pharmaceutical Financial Statement Overview

Summary
BioMarin Pharmaceutical demonstrates strong financial performance with significant revenue and profit growth. The company's income statement shows robust revenue growth from $2.09 billion in 2022 to $2.93 billion TTM, with improved profit margins. The balance sheet is solid with low leverage, and cash flow management is commendable with strong free cash flow growth. These factors enhance the company's financial stability and operational efficiency.
Income Statement
BioMarin Pharmaceutical has demonstrated a robust financial performance with strong revenue growth, rising from $2.09 billion in 2022 to $2.93 billion TTM (Trailing-Twelve-Months). The gross profit margin remains healthy, supported by efficient cost management. The net profit margin and EBIT margins have also shown significant improvement, indicating enhanced profitability. The consistent EBITDA margin growth highlights operational efficiency gains.
Balance Sheet
78
The company's balance sheet is strong, characterized by a low debt-to-equity ratio, suggesting prudent financial leverage. The equity ratio is impressive, indicating a high level of asset financing through equity. The return on equity has improved substantially, showcasing the company's ability to generate profits from shareholders' investments. However, the company should continue monitoring its debt levels to maintain financial flexibility.
Cash Flow
BioMarin Pharmaceutical has demonstrated strong cash flow dynamics with significant growth in free cash flow, reflecting effective capital expenditure management. The operating cash flow to net income ratio is favorable, indicating robust cash generation capabilities. The improved free cash flow to net income ratio further underscores the company's solid cash flow management.
Breakdown
Dec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income StatementTotal Revenue
2.85B2.42B2.10B1.85B1.86B
Gross Profit
2.27B1.84B1.61B1.38B1.34B
EBIT
484.21M194.44M57.55M-60.01M-96.26M
EBITDA
650.86M310.28M267.51M48.03M-5.85M
Net Income Common Stockholders
426.86M167.65M141.56M-64.08M854.03M
Balance SheetCash, Cash Equivalents and Short-Term Investments
1.14B1.07B1.29B1.01B1.07B
Total Assets
6.99B6.84B6.38B6.00B5.85B
Total Debt
602.71M1.10B1.08B1.08B1.08B
Net Debt
-340.13M340.62M358.49M491.80M425.99M
Total Liabilities
1.33B1.89B1.77B1.73B1.74B
Stockholders Equity
5.66B4.95B4.60B4.27B4.11B
Cash FlowFree Cash Flow
475.42M51.65M44.36M185.31M-52.15M
Operating Cash Flow
572.84M159.26M175.90M304.54M85.36M
Investing Cash Flow
136.49M-111.24M-20.03M-366.31M-53.62M
Financing Cash Flow
-526.45M-18.73M-18.65M-48.00K181.12M

BioMarin Pharmaceutical Technical Analysis

Technical Analysis Sentiment
Negative
Last Price59.82
Price Trends
50DMA
65.79
Negative
100DMA
65.48
Negative
200DMA
70.37
Negative
Market Momentum
MACD
-1.12
Negative
RSI
40.34
Neutral
STOCH
9.10
Positive
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For BMRN, the sentiment is Negative. The current price of 59.82 is below the 20-day moving average (MA) of 60.72, below the 50-day MA of 65.79, and below the 200-day MA of 70.37, indicating a bearish trend. The MACD of -1.12 indicates Negative momentum. The RSI at 40.34 is Neutral, neither overbought nor oversold. The STOCH value of 9.10 is Positive, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for BMRN.

BioMarin Pharmaceutical Risk Analysis

BioMarin Pharmaceutical disclosed 46 risk factors in its most recent earnings report. BioMarin Pharmaceutical reported the most risks in the “Finance & Corporate” category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

BioMarin Pharmaceutical Peers Comparison

Overall Rating
UnderperformOutperform
Sector (52)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
81
Outperform
$13.02B11.5423.16%30.43%82.29%
80
Outperform
$10.16B20.8023.13%18.49%176.71%
78
Outperform
$13.31B11.7719.94%19.85%21.16%
77
Outperform
$11.44B22.139.64%17.99%152.10%
75
Outperform
$11.54B184.440.47%17.13%-88.78%
52
Neutral
$9.83B357.68%10.69%34.71%
52
Neutral
$5.23B3.70-41.86%2.84%16.58%-0.16%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
BMRN
BioMarin Pharmaceutical
59.82
-21.90
-26.80%
EXEL
Exelixis
36.81
15.05
69.16%
INCY
Incyte
59.55
6.05
11.31%
UTHR
United Therapeutics
308.00
41.95
15.77%
ASND
Ascendis Pharma
159.39
26.26
19.73%
GMAB
Genmab
19.42
-9.39
-32.59%

BioMarin Pharmaceutical Earnings Call Summary

Earnings Call Date:May 01, 2025
(Q1-2025)
|
% Change Since: -4.61%|
Next Earnings Date:Aug 05, 2025
Earnings Call Sentiment Positive
BioMarin reported strong financial performance with notable revenue growth and profitability expansion, supported by successful pipeline progress. However, potential challenges include analyzing exposure to future pharmaceutical tariffs and managing VOXZOGO's revenue dynamics amid global order patterns. The overall sentiment leans towards optimism with strategic growth initiatives and robust financial results.
Q1-2025 Updates
Positive Updates
Strong Revenue Growth
BioMarin reported a 15% increase in total revenues for Q1 2025, reaching $745 million compared to the same period last year. VOXZOGO's global revenue also increased by 40% year-over-year.
Profitability Expansion
Non-GAAP earnings per share reached $1.13, representing a 59% year-over-year increase. Non-GAAP operating margin expanded by 11.9 percentage points year-over-year to 35.7%.
Pipeline Progress
Completed enrollment in a pivotal Phase 3 study with VOXZOGO in children with hypochondroplasia, aiming for a launch in 2027. Progress in BMN 351 for Duchenne Muscular Dystrophy and BMN 333, with early clinical results expected later this year.
Enzyme Therapies Growth
Revenue from the Enzyme Therapies business unit grew 8% year-over-year, with PALYNZIQ increasing by 22% compared to Q1 2024.
Geographical Revenue Diversification
Approximately two-thirds of BioMarin’s total revenues originate from outside the United States, providing insulation from US-specific economic conditions.
Negative Updates
Potential Tariff Impact
BioMarin is analyzing potential exposure to pharmaceutical tariffs under multiple scenarios, although they currently have immaterial exposure to US tariffs for China, Mexico, and Canada.
VOXZOGO Revenue Dynamics
Despite patient growth, quarterly revenues for VOXZOGO appear relatively similar quarter-to-quarter due to global order dynamics, with revenue growth expected mostly in the second half of 2025.
Company Guidance
In the BioMarin Pharmaceuticals First Quarter 2025 Conference Call, the company reported a strong financial performance with a 15% increase in revenue, reaching $745 million, and a 59% year-over-year rise in non-GAAP earnings per share, which stood at $1.13. The growth was fueled by VOXZOGO, which saw a 40% increase in global revenue to $214 million, and PALYNZIQ, which grew by 22%. The non-GAAP operating margin expanded to 35.7%, up by 11.9 percentage points from the previous year. The company reiterated its full-year non-GAAP operating margin guidance of 32% to 33%. BioMarin projects full-year 2025 VOXZOGO revenues between $900 million and $950 million, reflecting a 26% increase at the midpoint. The company also highlighted its strategic transformation, ongoing innovation, and robust global presence as key factors positioning it well amidst market uncertainties, with two-thirds of its revenue originating outside the United States.

BioMarin Pharmaceutical Corporate Events

Executive/Board Changes
BioMarin Expands Board with New Independent Director
Neutral
Feb 24, 2025

On February 20, 2025, BioMarin Pharmaceutical’s Board of Directors expanded from eleven to twelve members, appointing Timothy P. Walbert as an independent director effective February 24, 2025. Mr. Walbert will receive standard director fees and a pro rata share of the 2024 annual award of $400,000 in restricted stock units, with shares vesting before the next annual meeting of stockholders. This appointment does not result from any arrangement or related party transaction.

Glossary
OutperformA stock rated as "Outperform" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests that the stock is likely to deliver higher returns compared to the average returns of other stocks in the same sector or market index. Investors might consider this stock a good buying opportunity.
NeutralA stock rated as "Neutral" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly attractive nor unattractive for investment. Investors may consider holding onto the stock, as it is not expected to either significantly outperform or underperform the market.
UnderperformA stock rated as "Underperform" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests that the stock may deliver lower returns compared to the average returns of other stocks in the same sector or market index. Investors might consider selling the stock or avoiding it as an investment.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.