Transformational Partnership with Sarepta
Arrowhead and Sarepta entered into a licensing and collaboration agreement that could exceed $11 billion in value. The deal includes a $500 million upfront cash payment, a $325 million equity purchase at a 35% premium, and potential milestone payments ranging from $110 million to $410 million per program.
Plozasiran NDA Submission
Arrowhead submitted a New Drug Application to the FDA for plozasiran as a treatment for familial chylomicronemia syndrome (FCS). The application benefits from the FDA's breakthrough therapy designation, potentially speeding up the review process.
Strong Financial Position
Arrowhead's cash and investments at the end of fiscal 2024 were $681 million, which is expected to increase significantly with the Sarepta deal, extending their cash runway into 2028.
Positive Phase-3 Data for Plozasiran
The PALISADE study showed an 80% reduction from baseline in triglycerides with plozasiran, meeting its primary endpoint and significantly reducing the incidence of acute pancreatitis.
Expanding Cardiometabolic Focus
Arrowhead is focusing resources on a range of cardiometabolic programs, with a potential first commercial launch of plozasiran in 2025 and additional indications in severe hypertriglyceridemia (SHTG) by 2026.