CompetitionLebrikizumab received FDA approval with on-label dosing regimens corresponding to a minimum annualized WAC of $66.5k in year 1 and $45.5k thereafter, supporting a strong early launch that could read through positively to APG777.
Financial OutlookPatients who reported adverse effects of interest with Dupixent did not have the same experience on lebrikizumab, and the majority of patients discontinuing Dupixent due to adverse effects remained on lebrikizumab therapy.
Market ChallengesThe segment corresponds to a large opportunity, as >50% of Dupixent-treated patients have suboptimal responses and likely stay on Dupixent longer than otherwise appropriate, given the lack of post-Dupixent, non-JAK Tx options.