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Acrivon Therapeutics, Inc. (ACRV)
NASDAQ:ACRV
US Market

Acrivon Therapeutics, Inc. (ACRV) AI Stock Analysis

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Acrivon Therapeutics, Inc.

(NASDAQ:ACRV)

26Underperform
Acrivon's overall stock score is low due to significant financial challenges, including no revenue, increasing losses, and negative cash flows. The weak technical indicators further compound these concerns. However, recent corporate events showing progress in clinical programs and an extended cash runway offer some optimism for future prospects.
Positive Factors
Clinical Trials
Data in endometrial cancer shows strong clinical benefits, with a 35% overall response rate and 80% disease control rate.
Drug Development
Acrivon's OncoSignature assay improves patient selection effectiveness, potentially increasing response rates significantly compared to previous studies.
Financial Stability
The deprioritization of certain programs is expected to have a favorable impact on the company's cash runway, extending it into 2027.
Negative Factors
Financial Outlook
The need for approximately $300M additional financing through 2038 poses a financial risk.
Program Deprioritization
Acrivon is deprioritizing its ovarian and bladder cancer programs due to challenges in patient recruitment and higher efficacy expectations.
Stock Performance
ACRV shares traded down significantly following the clinical update, primarily due to the cessation of the ovarian and bladder programs.

Acrivon Therapeutics, Inc. (ACRV) vs. S&P 500 (SPY)

Acrivon Therapeutics, Inc. Business Overview & Revenue Model

Company DescriptionAcrivon Therapeutics, Inc., a clinical stage biopharmaceutical company, engages in developing oncology medicines for the patients whose tumors are predicted to be sensitive to each specific medicine by utilizing its proteomics-based patient responder identification platform. The company's Acrivon Predictive Precision Proteomics, a precision medicine platform enables the creation of drug specific proprietary OncoSignature companion diagnostics that are used to identify the patients to benefit from its drug candidates. Its lead clinical candidate is ACR-368, a selective small molecule inhibitor targeting CHK1 and CHK2, which is in a potentially registrational Phase 2 trial across various tumor types, including platinum-resistant ovarian, endometrial, and bladder cancer. The company is also developing its preclinical stage pipeline programs targeting critical nodes in the DNA damage response and cell cycle regulation pathways, such as WEE1, a protein kinase and PKMYT1, a protein serine/threonine kinase. The company was incorporated in 2018 and is based in Watertown, Massachusetts.
How the Company Makes MoneyAcrivon Therapeutics, Inc. makes money primarily through the development and commercialization of its targeted oncology therapies. The company generates revenue by advancing its drug candidates through clinical trials with the aim of obtaining regulatory approval and subsequently marketing these therapies. Key revenue streams include potential licensing agreements, partnerships with other pharmaceutical companies, and milestone payments upon achieving specific clinical and regulatory milestones. Additionally, Acrivon may engage in collaborative research and development agreements to enhance its pipeline and broaden its market reach.

Acrivon Therapeutics, Inc. Financial Statement Overview

Summary
Acrivon Therapeutics, Inc. is facing significant financial challenges with no revenue generation and increasing net losses. The company's balance sheet shows a strong equity position, but cash flow is concerning due to heavy reliance on external financing. Overall, the financial health of the company needs improvement to ensure long-term viability.
Income Statement
10
Very Negative
The company has not generated any revenue over the analyzed period, which is a significant concern. Net income has consistently been negative, and losses have widened over time, with EBIT and EBITDA showing a similar trend. The lack of revenue and increasing losses place the company in a challenging financial position.
Balance Sheet
45
Neutral
The company maintains a strong equity position relative to its liabilities, with a high equity ratio. However, the total debt has been managed at a low level, which is a positive sign. Despite these strengths, the consistent net losses reduce the overall value of the equity position.
Cash Flow
30
Negative
Operating cash flow has been consistently negative, indicating that the company is not generating enough cash to cover its operating expenses. Free cash flow is also negative, and the company relies heavily on financing activities to offset cash deficits. This reliance poses potential long-term sustainability risks.
Breakdown
TTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income StatementTotal Revenue
1.88M0.000.000.000.000.00
Gross Profit
1.31M0.00-536.00K-1.09M-832.00K-13.00K
EBIT
-85.30M-89.20M-67.24M-32.66M-16.18M-3.17M
EBITDA
-84.92M-89.20M-59.85M-30.07M-15.41M-5.29M
Net Income Common Stockholders
-76.98M-80.56M-60.39M-29.68M-16.24M-5.31M
Balance SheetCash, Cash Equivalents and Short-Term Investments
99.60M179.48M127.46M127.75M99.60M1.58M
Total Assets
106.59M196.59M138.26M181.23M106.59M2.19M
Total Debt
5.63M3.65M4.64M4.96M5.63M58.00K
Net Debt
-93.97M-36.17M-31.37M-24.56M-93.97M-1.52M
Total Liabilities
130.40M19.80M17.07M10.75M130.40M10.60M
Stockholders Equity
-23.81M176.79M121.19M170.47M-23.81M-8.41M
Cash FlowFree Cash Flow
-63.77M-68.44M-43.93M-32.28M-14.22M-2.82M
Operating Cash Flow
-60.67M-65.67M-42.64M-30.12M-13.98M-2.80M
Investing Cash Flow
-45.65M-51.77M50.72M-141.68M-238.00K-15.00K
Financing Cash Flow
119.66M121.03M-1.55M101.71M112.22M2.89M

Acrivon Therapeutics, Inc. Technical Analysis

Technical Analysis Sentiment
Negative
Last Price1.74
Price Trends
50DMA
5.04
Negative
100DMA
5.86
Negative
200DMA
6.77
Negative
Market Momentum
MACD
-0.85
Positive
RSI
19.94
Positive
STOCH
2.02
Positive
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For ACRV, the sentiment is Negative. The current price of 1.74 is below the 20-day moving average (MA) of 4.22, below the 50-day MA of 5.04, and below the 200-day MA of 6.77, indicating a bearish trend. The MACD of -0.85 indicates Positive momentum. The RSI at 19.94 is Positive, neither overbought nor oversold. The STOCH value of 2.02 is Positive, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for ACRV.

Acrivon Therapeutics, Inc. Risk Analysis

Acrivon Therapeutics, Inc. disclosed 80 risk factors in its most recent earnings report. Acrivon Therapeutics, Inc. reported the most risks in the “Tech & Innovation” category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Acrivon Therapeutics, Inc. Peers Comparison

Overall Rating
UnderperformOutperform
Sector (48)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
68
Neutral
$6.01B26.2119.71%52.97%
55
Neutral
$33.27B-414.62%22.97%38.54%
52
Neutral
$5.49B-31.26%104.04%87.80%
49
Neutral
$4.33B-93.03%-10.48%-18.79%
48
Neutral
$6.86B1.11-50.22%2.47%16.71%1.53%
36
Underperform
$51.40M-295.35%184.12%31.92%
26
Underperform
$52.67M-54.07%10.84%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
ACRV
Acrivon Therapeutics, Inc.
1.64
-5.05
-75.49%
ALNY
Alnylam Pharma
262.16
110.68
73.07%
IONS
Ionis Pharmaceuticals
28.52
-14.31
-33.41%
SRPT
Sarepta Therapeutics
58.61
-67.18
-53.41%
BLUE
Bluebird Bio
4.89
-19.71
-80.12%
BPMC
Blueprint Medicines
87.11
-3.57
-3.94%

Acrivon Therapeutics, Inc. Corporate Events

Business Operations and StrategyFinancial Disclosures
Acrivon Therapeutics Reports 2024 Financial Results and Progress
Positive
Mar 27, 2025

On March 27, 2025, Acrivon Therapeutics announced its financial results for the fourth quarter and full year 2024, highlighting significant progress in its clinical programs. The company reported promising data from its ACR-368 trials for endometrial cancer, showing a high response rate in heavily pretreated patients, and prioritized this cancer type due to limited treatment options and commercial potential. Additionally, the Phase 1 trial of ACR-2316 is ahead of schedule, with early signs of clinical activity. Acrivon has extended its cash runway into 2027, allowing continued focus on its AP3 platform and drug development efforts.

Executive/Board Changes
Acrivon Therapeutics Appoints New Chief Financial Officer
Neutral
Mar 14, 2025

On March 14, 2025, Acrivon Therapeutics announced the appointment of Adam Levy, Ph.D., M.B.A., as Chief Financial Officer effective April 1, 2025. Dr. Levy brings over 25 years of experience in finance and investor relations within the biopharma sector, having previously held senior roles at companies like Zentalis Pharmaceuticals and Gilead Sciences. His appointment follows the departure of Rasmus Holm-Jorgensen, who is stepping down for personal reasons to pursue an opportunity in Europe. This leadership change is not due to any disagreements within the company, and it is expected to strengthen Acrivon’s financial strategy and investor relations.

Glossary
OutperformA stock rated as "Outperform" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests that the stock is likely to deliver higher returns compared to the average returns of other stocks in the same sector or market index. Investors might consider this stock a good buying opportunity.
NeutralA stock rated as "Neutral" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly attractive nor unattractive for investment. Investors may consider holding onto the stock, as it is not expected to either significantly outperform or underperform the market.
UnderperformA stock rated as "Underperform" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests that the stock may deliver lower returns compared to the average returns of other stocks in the same sector or market index. Investors might consider selling the stock or avoiding it as an investment.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.