OpRegen Program Progress
The OpRegen program, a cell transplant for dry AMD, is progressing well with the GAlette Study managed by partners Roche and Genentech. The study has been enrolling for nearly two years, and recent actions by Roche indicate a positive direction. Additionally, a three-year clinical update from the Phase 1/2a trial shows that the benefits have persisted.
Manufacturing Advancements
Lineage has been investing in scalable cell therapy manufacturing, aiming to deliver millions of doses. This effort has generated new intellectual property and achieved specific milestones, differentiating Lineage's capabilities in the cell therapy field.
Financial Strength and Strategy
Lineage reported cash, cash equivalents, and marketable securities of $47.8 million as of December 31, 2024, with an extended runway into Q1 2027. The company's financing strategy includes a milestone warrant that could access an additional $36 million, contingent on clinical success.