Clinical Trials And EfficacyIONS announced discontinuation of IONIS-FB-LRx for geographic atrophy (GA) and ION541 for amyotrophic lateral sclerosis (ALS) as both assets demonstrated insufficient efficacy to advance into Phase 3.
Drug Development And PipelineIONS has advanced too many promising drugs that inevitably reduce focus, consume resources, and increase ambiguity around the size/fate of each opportunity.
Financial PerformanceUpdating the model for the offering reduces the price target from $62 to $56.