Competitive ThreatsAn oral competitor, infigratinib, could potentially become the dominant therapy for achondroplasia due to its more convenient dosing profile.
Financial PerformanceThe valuation multiple used by the analyst has decreased from 35x to 25x, suggesting a less aggressive growth expectation.
Management ExecutionThe Skytrofa revenue miss and guidance revision highlight management's execution, which investors see as a risk to the US Yorvipath launch.