Ivonescimab Collaboration with Pfizer
Summit announced a clinical trial collaboration with Pfizer to evaluate Ivonescimab in combination with multiple Pfizer ADCs in solid tumor settings, with trials expected to start mid-2025.
Progress on Global Phase III Trials
Summit completed enrollment in the HARMONi Phase III trial for EGFR mutated non-small cell lung cancer and received Fast Track designation. The HARMONi-3 protocol was expanded to include both squamous and non-squamous histologies, doubling the patient population.
Strong Financial Position
Summit ended 2024 with $412 million in cash and no debt, enabling continued execution of clinical trials.
Ivonescimab Development Milestones
Ivonescimab was featured in 14 publications across 7 tumor types in 2024 and was selected for five oral presentations at major medical conferences.
Global Clinical Trials and Expansions
Summit and Akeso have multiple Phase III trials underway for Ivonescimab, including new indications like pancreatic cancer.