Clinical TrialsPhase 2 DIMENSION trial evaluating dalzanemdor in cognitive impairment associated with Huntington’s disease did not meet the primary endpoint, and no statistically significant or clinically meaningful differences were seen on secondary endpoints.
Financial OutlookRemoval of dalzanemdor value lowers the price target to $9 from a prior $10, reflecting diminished expectations due to multiple clinical setbacks.
Strategic UncertaintyVisibility around how SAGE might put its $569 million in cash to work remains poor, raising concerns about strategic direction and potential impact on stock performance.