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PYXS Stock Chart & Stats
$3.06
$0.30(11.49%)
At close: 4:00 PM EDT
$3.06
$0.30(11.49%)
Day’s Range― - ―
52-Week Range$1.03 - $5.55
Previous CloseN/A
Volume197.33K
Average Volume (3M)822.09K
Market Cap
$243.55M
Enterprise Value$175.98
Total Cash (Recent Filing)$33.00M
Total Debt (Recent Filing)$17.83M
Price to Earnings (P/E)―
Beta1.59
Next Earnings
Nov 17, 2026EPS Estimate
-0.28Next Dividend Ex-DateN/A
Dividend YieldN/A
Share Statistics
EPS (TTM)-1.41
Shares Outstanding83,408,050
10 Day Avg. Volume628,909
30 Day Avg. Volume822,094
Financial Highlights & Ratios
PEG Ratio0.30
Price to Book (P/B)1.34
Price to Sales (P/S)5.16
P/FCF Ratio-1.13
Enterprise Value/Market Cap<0.01
Enterprise Value/Revenue<0.01
Enterprise Value/Gross Profit<0.01
Enterprise Value/Ebitda>-0.01
Forecast
1Y Price Target
$8.71Price Target Upside184.78% Upside
Rating ConsensusStrong Buy
Number of Analyst Covering8
EPS Forecast (FY)-1.22
Revenue Forecast (FY)$57.14K
Bulls Say, Bears Say
Bulls Say
MICVO Clinical ProgressThe reported response and disease-control rates provide meaningful clinical validation for Pyxis’s lead asset. Promising durability, manageable safety, and planned Phase 3 advancement could improve the company’s competitive position and support future partnering or commercialization potential.
Extended Financing RunwayThe financing gives Pyxis additional time to fund MICVO development and generate follow-up clinical data before needing another capital raise. A longer runway supports execution of planned studies and reduces immediate financing pressure while key milestones approach.
Leadership StabilizationConsolidating leadership under a permanent CEO can improve accountability and strategic continuity during an important clinical development period. Civik’s prior cancer-focused biotechnology experience may also support disciplined execution as MICVO advances toward later-stage testing.
Bears Say
Heavy Operating Cash BurnSubstantial recurring cash consumption shows that Pyxis is not self-funding its operations and remains dependent on external capital. Continued burn can constrain development choices, increase dilution risk, and make future financing conditions important to maintaining the pipeline.
Large Operating LossesThe wide gap between small, declining revenue and large operating losses indicates that Pyxis has not yet established an earnings-supporting commercial base. Until development spending produces durable revenue, profitability remains highly dependent on clinical and financing milestones.
Weakened Balance SheetHigher leverage alongside a shrinking asset and equity base leaves Pyxis with a weaker financial cushion. This reduces flexibility to absorb setbacks or fund development internally and increases dependence on additional financing as clinical programs advance.
PYXS FAQ
What was Pyxis Oncology’s price range in the past 12 months?
Pyxis Oncology lowest stock price was $1.03 and its highest was $5.55 in the past 12 months.
What is Pyxis Oncology’s market cap?
Pyxis Oncology’s market cap is $243.55M.
When is Pyxis Oncology’s upcoming earnings report date?
Pyxis Oncology’s upcoming earnings report date is Nov 17, 2026 which is in 51 days.
How were Pyxis Oncology’s earnings last quarter?
Pyxis Oncology released its earnings results on Aug 13, 2026. The company reported -$0.4 earnings per share for the quarter, missing the consensus estimate of -$0.35 by -$0.05.
Is Pyxis Oncology overvalued?
According to Wall Street analysts Pyxis Oncology’s price is currently Undervalued.
Does Pyxis Oncology pay dividends?
Pyxis Oncology does not currently pay dividends.
What is Pyxis Oncology’s EPS estimate?
Pyxis Oncology’s EPS estimate is -0.28.
How many shares outstanding does Pyxis Oncology have?
Pyxis Oncology has 83,408,050 shares outstanding.
What happened to Pyxis Oncology’s price movement after its last earnings report?
Pyxis Oncology reported an EPS of -$0.4 in its last earnings report, missing expectations of -$0.35. Following the earnings report the stock price went down -5.346%.
Which hedge fund is a major shareholder of Pyxis Oncology?
Currently, no hedge funds are holding shares in PYXS
What is the TipRanks Smart Score and how is it calculated?
Smart Score combines eight research factors - such as analyst recommendations, hedge fund trends, and technical indicators - to measure a stock’s outlook. These signals are unified into a single score that reflects bullish or bearish momentum. See detailed methodology
Pyxis Oncology Stock Smart Score
Outperform
1
2
3
4
5
6
7
8
9
10
Analyst Consensus
Strong Buy
Average Price Target:
$8.71 (184.78% Upside)
$8.71 (184.78% Upside)
Blogger Sentiment
Neutral
PYXS Sentiment 50%
Sector Average 63%
Sector Average 63%
Hedge Fund Trend
Increased
By 524.0K Shares
Last Quarter.
Last Quarter.
Crowd Wisdom
Positive
Last 7 Days ▼ 2.1%
Last 30 Days ▲ 3.3%
Last 30 Days ▲ 3.3%
News Sentiment
Very Bullish
Bullish news 100%
Bearish news 0%
Bearish news 0%
Technicals
SMA
Positive
20 days / 200 days
Momentum
38.83%
12-Months-Change
Fundamentals
Return on Equity
―
Trailing 12-Months
Asset Growth
-55.43%
Trailing 12-Months
Learn more about TipRanks Smart Score
Company Description
Pyxis Oncology
Pyxis Oncology, Inc. operates as a preclinical biopharmaceutical company focused on developing novel therapeutic approaches to combat various forms of cancer. Its investigational immune-oncology pipeline includes PYX-106, a fully human immunoglobulin G1 (IgG1) antibody designed to target siglec-15, which is being explored for its potential efficacy against thyroid cancer, head and neck squamous cell carcinoma, non-small cell lung cancer (NSCLC), and other solid tumors. Additionally, PYX-102 is an immune-therapeutic currently under investigation for the treatment of solid tumors. The company's portfolio also features a range of investigational antibody-drug conjugate (ADC) candidates: PYX-201, a novel ADC being developed for NSCLC, breast cancer, and other solid tumors; PYX-202, another novel ADC aimed at small cell lung cancer (SCLC), soft tissue sarcoma, and other solid tumors; and PYX-203, an ADC undergoing evaluation for acute myeloid leukemia and myeloid dysplastic syndrome. Pyxis Oncology was founded in 2018 and is based in Cambridge, Massachusetts.
PYXS Stock 12 Month Forecast
Average Price Target
$8.71
▲(184.78% Upside)
Technical Analysis
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Ownership Overview
2.14% Insiders
3.08% Mutual Funds
32.10% Other Institutional Investors
58.93% Public Companies and Individual Investors








