Efficacy And Response RatesIn HPV16-positive subgroup, the overall response rate increased to 62.5% by RECISTv1.1 and 75% by irRECIST, well above the 12-24% typically observed with standard-of-care ICIs.
Phase III Trial ProspectsPDS Biotechnology's Versamune HPV demonstrated compelling efficacy in the Phase II VERSATILE-002 trial, setting the stage for a Phase III initiation.
Survival RatesPatients who had undetectable HPV16 ctDNA at 3-4 months showed an improved two-year recurrence-free survival rate of 93%, compared to 30% in those with detectable ctDNA.