Acquisition ChallengesThe acquisition of ImmPACT Bio for its CD19/ CD20 CAR-T IMPT-314 raises eyebrows and complicates the story.
Market CompetitionThe CD19-targeted CAR-T space is crowded, and the opportunity for another entrant like Lyell is limited.
Pipeline DevelopmentDevelopment of several legacy pipeline programs, including LYL797 and LYL845, has been discontinued with no sufficient evidence of benefits from the second-generation ROR1 CAR-T.