Clinical TrialsSafety concerns with the second lead asset, cibotercept, following observation of pericardial effusion in their ongoing Phase 2 study, led to a significant pullback in the stock.
Market SentimentUnexpected safety findings have cast doubt on the efficacy of Keros Therapeutics' trials at lower doses, with investors requiring more data to be comfortable with the safety profile.
Regulatory And Commercial RiskThe unexpected safety signal and changes to KROS’ Phase 2 TROPOS study of cibotercept in pulmonary arterial hypertension significantly increases the clinical, regulatory, and commercial risk for this asset.