Investor ConcernsInvestors expressed concerns regarding on-target KIT toxicities such as neutropenia, hair and skin color changes, as well as discontinuation rates.
Program DiscontinuationThe LR-MDS program has been discontinued, and it is removed from the valuation of JSPR.
Safety ConcernsDiscontinuation rates increased significantly (25%) with 8%-13% being driven by on-target adverse effects.