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Jazz Pharmaceuticals (JAZZ)
NASDAQ:JAZZ

Jazz Pharmaceuticals (JAZZ) AI Stock Analysis

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Jazz Pharmaceuticals

(NASDAQ:JAZZ)

73Outperform
Jazz Pharmaceuticals scores well on financial strength and strategic initiatives, bolstered by a promising acquisition. However, technical challenges and potential revenue impacts from generics temper the outlook. The company's solid financials and strategic acquisitions support a positive long-term view, but current technical trends and valuation caution suggest a moderate overall score.
Positive Factors
Financial performance
Jazz's stock is considered undervalued with a price objective significantly higher than the current trading price, suggesting upside potential.
Manufacturing strategy
Jazz Pharmaceuticals is expected to mitigate tariff impacts by working down inventory that is already in the US.
Product pipeline
The acquisition of Chimerix is expected to be highly accretive and bolster Jazz Pharmaceuticals' rare oncology portfolio.
Negative Factors
Earnings impact
Assuming tariffs start and last through the entirety of Trump's term, there is an estimated $(0.57) FY'25 EPS impact.
Investor sentiment
Investors are seen as cautious but the company's ability to accelerate US production could serve as a positive catalyst.
Tariffs impact
Jazz's stock has traded down ~12% since Trump mentioned potential pharma tariffs on Irish drug imports.

Jazz Pharmaceuticals (JAZZ) vs. S&P 500 (SPY)

Jazz Pharmaceuticals Business Overview & Revenue Model

Company DescriptionJazz Pharmaceuticals plc, a biopharmaceutical company, identifies, develops, and commercializes pharmaceutical products for various unmet medical needs in the United States, Europe, and internationally. The company has a portfolio of products and product candidates with a focus in the areas of neuroscience, including sleep medicine and movement disorders; and in oncology, including hematologic and solid tumors. Its lead marketed products include Xyrem, an oral solution for the treatment of cataplexy and excessive daytime sleepiness (EDS) in narcolepsy patients seven years of age and older; Sunosi for the treatment of EDS in patients with narcolepsy and obstructive sleep apnea; Erwinaze to treat acute lymphoblastic leukemia; Defitelio for the treatment of adult and pediatric patients with hepatic veno-occlusive disease; Vyxeos liposome for injection, a product for the treatment of adults with newly-diagnosed therapy-related acute myeloid leukemia; and Zepzelca for the treatment of adult patients with metastatic small cell lung cancer. The company also offers Xywav, an oxybate product candidate, to treat EDS and cataplexy with narcolepsy and idiopathic hypersomnia; JZP-324, a low sodium oxybate formulation with the potential to provide a clinically meaningful option for narcolepsy patients; JZP385, a T-type calcium channel modulator, for the treatment of essential tremor; JZP458, a recombinant Erwinia asparaginase, for use as a component of a multi-agent chemotherapeutic regimen in the treatment of pediatric and adult patients; and JZP150 for treatment of post-traumatic stress disorder. The company has licensing and collaboration agreements with ImmunoGen, Inc.; Codiak BioSciences, Inc.; Pfenex, Inc.; XL-protein GmbH; and Redx Pharma plc. Jazz Pharmaceuticals plc was incorporated in 2003 and is headquartered in Dublin, Ireland.
How the Company Makes MoneyJazz Pharmaceuticals generates revenue through the sale of its pharmaceutical products, primarily in the fields of sleep medicine and oncology. The company's revenue model is heavily reliant on its flagship products, such as Xyrem, a treatment for cataplexy and excessive daytime sleepiness in narcolepsy patients, and Vyxeos, a chemotherapy treatment for specific types of acute myeloid leukemia (AML). Additionally, Jazz invests in research and development to expand its product portfolio and pipeline, aiming to bring new and innovative treatments to market. The company also engages in strategic partnerships and collaborations to enhance its research capabilities and expand its market reach. Key revenue streams include product sales, licensing agreements, and collaborations with other pharmaceutical companies.

Jazz Pharmaceuticals Financial Statement Overview

Summary
Jazz Pharmaceuticals demonstrates strong financial performance, marked by solid revenue growth and impressive cash flow management. The company's balance sheet shows stability with low leverage, although there is room for improvement in net profitability and equity strengthening.
Income Statement
85
Very Positive
Jazz Pharmaceuticals has shown strong revenue growth with a 6.12% increase from 2023 to 2024. The gross profit margin is excellent, at 100%, indicating effective cost management. The EBIT margin improved to 17.61%, reflecting better operational efficiency. However, the net profit margin is at 13.77%, indicating room for improvement in controlling non-operational expenses.
Balance Sheet
70
Positive
The company has a low debt-to-equity ratio of 0.02, showcasing strong leverage management. The return on equity is 13.68%, which is healthy but could be improved. The equity ratio stands at 34.07%, indicating a balanced capital structure but with a relatively high level of liabilities.
Cash Flow
90
Very Positive
Jazz Pharmaceuticals exhibits an impressive free cash flow growth rate of 30.69% from 2023 to 2024. The operating cash flow to net income ratio is 2.49, suggesting strong cash generation relative to net income. The free cash flow to net income ratio is 2.49, indicating robust cash flow management.
Breakdown
Dec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income StatementTotal Revenue
4.07B3.83B3.66B3.09B2.36B
Gross Profit
4.07B3.40B3.12B2.65B2.21B
EBIT
716.63M578.58M512.27M170.28M765.46M
EBITDA
716.63M1.23B553.78M1.03B649.65M
Net Income Common Stockholders
560.12M414.83M-214.14M-328.95M238.62M
Balance SheetCash, Cash Equivalents and Short-Term Investments
2.99B1.63B881.48M591.45M2.13B
Total Assets
12.01B11.39B10.84B12.30B6.54B
Total Debt
69.94M5.79B5.80B6.14B2.23B
Net Debt
-2.34B4.29B4.91B5.55B1.18B
Total Liabilities
7.92B7.66B7.75B8.33B2.88B
Stockholders Equity
4.09B3.74B3.09B3.97B3.66B
Cash FlowFree Cash Flow
1.35B1.07B773.78M732.98M520.39M
Operating Cash Flow
1.40B1.09B1.27B778.51M899.65M
Investing Cash Flow
-508.19M-163.06M-446.23M-5.21B-1.01B
Financing Cash Flow
20.52M-305.25M-529.49M3.97B528.07M

Jazz Pharmaceuticals Technical Analysis

Technical Analysis Sentiment
Negative
Last Price103.38
Price Trends
50DMA
127.75
Negative
100DMA
125.17
Negative
200DMA
118.43
Negative
Market Momentum
MACD
-8.32
Positive
RSI
35.06
Neutral
STOCH
39.94
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For JAZZ, the sentiment is Negative. The current price of 103.38 is below the 20-day moving average (MA) of 112.85, below the 50-day MA of 127.75, and below the 200-day MA of 118.43, indicating a bearish trend. The MACD of -8.32 indicates Positive momentum. The RSI at 35.06 is Neutral, neither overbought nor oversold. The STOCH value of 39.94 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for JAZZ.

Jazz Pharmaceuticals Risk Analysis

Jazz Pharmaceuticals disclosed 44 risk factors in its most recent earnings report. Jazz Pharmaceuticals reported the most risks in the “Legal & Regulatory” category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Jazz Pharmaceuticals Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
73
Outperform
$6.28B11.8814.31%6.12%38.88%
71
Outperform
$7.08B16.69198.42%22.44%63.47%
51
Neutral
$7.44B1.93-7.10%-20.84%-102.48%
51
Neutral
$5.20B3.18-40.80%2.96%17.66%1.94%
48
Neutral
$5.92B-15.45%119.97%67.21%
46
Neutral
$6.49B35.68%2285.27%27.90%
45
Neutral
$6.51B-80.35%-10.89%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
JAZZ
Jazz Pharmaceuticals
104.19
-4.13
-3.81%
HALO
Halozyme
58.41
19.29
49.31%
MDGL
Madrigal Pharmaceuticals
308.79
104.14
50.89%
BBIO
BridgeBio Pharma
35.23
10.20
40.75%
LEGN
Legend Biotech
34.30
-10.87
-24.06%
ROIV
Roivant Sciences
10.74
-0.16
-1.47%

Jazz Pharmaceuticals Earnings Call Summary

Earnings Call Date: Feb 25, 2025 | % Change Since: -25.98% | Next Earnings Date: May 6, 2025
Earnings Call Sentiment Positive
The earnings call highlighted significant achievements, including record revenues, successful product launches, and strong sales growth for key products like Epidiolex. However, challenges such as the impact of pediatric protocol changes on Rylaze and potential revenue erosion from upcoming generic competition were noted. The company demonstrated financial strength by reducing debt and maintaining strategic flexibility.
Highlights
Record Annual and Quarterly Revenue
Jazz Pharmaceuticals reported over $4 billion in total annual revenue for 2024 and nearly $1.1 billion in fourth quarter revenue, marking the highest ever quarterly revenue.
Strong Growth in Epidiolex Sales
Epidiolex net product revenues grew 15% in 2024 compared to 2023, showing strong underlying demand and positioning the product to reach blockbuster status in 2025.
Successful Launch of Ziihera
Ziihera received accelerated approval in the U.S. for HER2-positive biliary tract cancer and generated positive initial feedback from healthcare providers.
Zepzelca Phase III Clinical Success
Positive results from the Phase III trial for Zepzelca in first-line maintenance for small cell lung cancer, indicating potential for expanded use.
Financial Flexibility and Debt Reduction
Significant cash generation allowed for a $750 million voluntary repayment on Term Loan B, reducing leverage substantially.
Lowlights
Impact from Pediatric Protocol Changes
Changes to pediatric protocols temporarily impacted Rylaze's revenue in the second half of 2024.
Potential Revenue Erosion from Generics
Concerns about rapid erosion of Xyrem revenue as authorized and full generics could enter the market, impacting high sodium oxybate AG royalty revenue.
Timing of Clinical Data Readouts
The data readout for the HERIZON-GEA-01 Phase III trial evaluating zanidatamab was delayed to the second half of 2025.
Company Guidance
In the recent earnings call, Jazz Pharmaceuticals provided comprehensive guidance for 2025, highlighting several key metrics. The company reported total revenues of approximately $4.1 billion for 2024, marking a 6% increase over 2023, and expects 2025 revenues to range between $4.15 billion and $4.4 billion. They achieved a non-GAAP adjusted net income of about $1.37 billion in 2024, with an adjusted EPS of $20.90. Jazz anticipates continued growth in 2025, driven by strong performance in their sleep, epilepsy, and oncology portfolios, with Xywav and Epidiolex poised to drive significant revenue. The company also highlighted a reduction in non-GAAP adjusted R&D expenses by 8% from 2024, focusing on priority programs like zanidatamab. Additionally, they expect adjusted net income for 2025 to range from $1.4 billion to $1.5 billion, reflecting their strategic investments and disciplined expense management.

Jazz Pharmaceuticals Corporate Events

M&A Transactions
Jazz Pharmaceuticals Completes Acquisition of Chimerix
Positive
Apr 21, 2025

On April 21, 2025, Jazz Pharmaceuticals announced the completion of its acquisition of Chimerix, Inc. for approximately $935 million. This acquisition enhances Jazz’s oncology pipeline with the addition of dordaviprone, a novel treatment under FDA Priority Review for H3 K27M-mutant diffuse glioma. The merger positions Jazz to potentially offer the first FDA-approved therapy for this condition, reflecting a significant commercial opportunity and reinforcing its commitment to addressing rare diseases with unmet needs.

Spark’s Take on JAZZ Stock

According to Spark, TipRanks’ AI Analyst, JAZZ is a Neutral.

Jazz Pharmaceuticals presents a mixed outlook. Strong financial performance and strategic acquisitions support a positive long-term view. However, current technical indicators suggest a challenging stock trend in the short term. Valuation appears favorable with a low P/E ratio, but the lack of dividends and potential revenue impacts from generic competition add caution. The earnings call’s positive sentiment and strategic initiatives, despite some challenges, contribute to a moderately positive score.

To see Spark’s full report on JAZZ stock, click here.

M&A Transactions
Jazz Pharmaceuticals to Acquire Chimerix in $935M Deal
Positive
Mar 5, 2025

On March 4, 2025, Jazz Pharmaceuticals announced a merger agreement to acquire Chimerix for $8.55 per share, totaling approximately $935 million. This acquisition will enhance Jazz’s oncology portfolio by adding dordaviprone, a treatment for H3 K27M-mutant diffuse glioma, a rare brain tumor. The transaction, approved by both companies, is expected to close in the second quarter of 2025. Dordaviprone, which has shown promising clinical trial results, is under FDA review for accelerated approval. The acquisition is anticipated to strengthen Jazz’s presence in the rare oncology space and provide a significant commercial opportunity, potentially making dordaviprone a standard of care for this rare disease.

Glossary
OutperformA stock rated as "Outperform" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests that the stock is likely to deliver higher returns compared to the average returns of other stocks in the same sector or market index. Investors might consider this stock a good buying opportunity.
NeutralA stock rated as "Neutral" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly attractive nor unattractive for investment. Investors may consider holding onto the stock, as it is not expected to either significantly outperform or underperform the market.
UnderperformA stock rated as "Underperform" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests that the stock may deliver lower returns compared to the average returns of other stocks in the same sector or market index. Investors might consider selling the stock or avoiding it as an investment.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.