Efficacy ConcernsThe Ph3 study of IO102-IO103 + pembro in 1L advanced melanoma did not meet the very high bar for success (P<0.005) on the interim ORR analysis, as expected.
Safety ProfileThe safety profile showed Grade 3-4 treatment-related adverse events in 24% of patients, which is slightly higher than some comparable studies.
Study Outcome UncertaintyThe chances of the interim analysis hitting are low given the high stats bar and leave a positive outcome as upside.