Safety ConcernsThe safety profile showed Grade 3-4 treatment-related adverse events in 24% of patients, which is slightly higher than some comparable studies.
Study ResultsThe interim results from the Phase 3 study did not meet statistical significance, and there is uncertainty regarding the numerical benefit in the treatment arm as the ORR numbers were not disclosed.
Treatment EfficacyIO102-IO103 appears to be marginally additive to pembro alone based on KEYNOTE-024 and -042 studies, with an updated ORR that is only marginally additive to pembro alone of less than 10%.