Yesterday, Structure Therapeucs (Nasdaq: GPCR) announced the selecon of a development candidate for its oral small molecule dual amylin and calcitonin receptor agonist (DACRA) program. The candidate, ACCG-2671, will enter IND-enabling studies in the first half of 2025 and is being developed for the treatment of obesity. In preclinical studies, ACCG-2671 demonstrated in vitro nanomolar binding affinity toward both the amylin receptor (Ki <5 nM) and the calcitonin receptor (Ki <5 nM), along with sub-nanomolar in vitro funconal acvity ag ainst both receptors. In a DIO rat model, repeat once-daily (QD) dosing of 15 mpk 28 days resulted in a 14.8% reducon in body weight. In the same DIO model, Novo Nordisk's (NYSE: NVO) pepde DACRA, cagrilinde, achieved a comparable 11.4% weight loss at a 7.5 nmol/kg dose.