Clinical Trial SuccessMitapivat's RISE-UP trial will be successful on the co-primary endpoint of VOC reduction, support multi-billion dollar sales, and make AGIO shares a top performer in 2025.
Efficacy And SafetyMitapivat and the PKR class have not shown possible immunosuppressive effects, which could be a differentiating factor from Oxbryta.
Market OpportunityThe withdrawal of a key competitor, Oxbryta, from the SCD market could potentially benefit Agios Pharmaceuticals.