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89bio (ETNB)
NASDAQ:ETNB
US Market

89bio (ETNB) AI Stock Analysis

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89bio

(NASDAQ:ETNB)

42Neutral
89bio's stock score reflects the typical high-risk, high-reward profile of early-stage biotech firms. The lack of revenue and operational losses weigh heavily on the financial performance score. Bearish technical indicators add to the cautious outlook. While the valuation is low, the positive clinical progress update provides some strategic reassurance, underscoring potential future growth contingent on successful product commercialization.
Positive Factors
Clinical Trials
Phase 3 NASH timelines remain on track, with significant future revenue opportunities projected for fibrotic and cirrhotic NASH.
Regulatory Approval
Plans for accelerated and conditional approval in the U.S. and Europe for pegozafermin based on positive data from the ENLIGHTEN trials indicate potential future success.
Study Results
Positive results from the earlier Phase 2 ENTRIGUE study showed impressive reductions in triglycerides, boosting confidence in pegozafermin's effectiveness for SHTG.
Negative Factors
Clinical Trial Delays
The decision to delay the data readout for the ENTRUST study was made following discussions with the FDA to reduce potential bias, not due to any unexpected safety or efficacy findings.
Competition
Potential implications on pegozafermin’s regulatory pathway, physician prescribing, and access/reimbursement due to strong launch of a competitor's product.
Regulatory Challenges
A second pivotal trial in SHTG will be required for approval, potentially delaying the BLA filing process.

89bio (ETNB) vs. S&P 500 (SPY)

89bio Business Overview & Revenue Model

Company Description89bio, Inc., a clinical-stage biopharmaceutical company, focuses on the development and commercialization of therapies for the treatment of liver and cardio-metabolic diseases. Its lead product candidate is pegozafermin, a glycoPEGylated analog of fibroblast growth factor 21 for the treatment of nonalcoholic steatohepatitis. The company also intends to develop pegozafermin for the treatment of severe hypertriglyceridemia. 89bio, Inc. was incorporated in 2018 and is headquartered in San Francisco, California.
How the Company Makes Money89bio makes money primarily through the development and eventual commercialization of its lead product candidate, pegozafermin. The company's revenue model is focused on progressing its candidate through various stages of clinical trials with the goal of achieving regulatory approval for commercial sale. Key revenue streams are expected to arise from licensing agreements, partnerships with larger pharmaceutical companies, and eventual product sales. 89bio may also secure funding through strategic collaborations and potential milestone payments associated with the development and commercialization of its therapeutic solutions. As a clinical-stage company, 89bio currently does not generate revenue from product sales but is actively engaged in research and development activities to bring its therapies to market.

89bio Financial Statement Overview

Summary
89bio is in a typical biotechnology industry situation where the focus is on research and development with no revenue generation yet. The company's financial health heavily relies on its strong cash reserves and ability to secure financing. The absence of revenue and consistent operational losses highlight the high-risk, high-reward nature of investing in such early-stage biotech firms. Future financial health depends on successful R&D outcomes and eventual product commercialization or continued investor support.
Income Statement
15
Very Negative
89bio has not generated any revenue over the years, indicating no sales activity, which is common in early-stage biotechnology firms focused on research and development. The company consistently reported negative EBIT and net income, reflecting ongoing operational losses. The lack of revenue and persistent losses highlight the company's reliance on external funding and the high-risk nature of its current stage.
Balance Sheet
60
Neutral
The company's balance sheet shows a strong cash position with significant cash and short-term investments relative to its total liabilities, leading to a negative net debt. The debt-to-equity ratio is low, indicating limited leverage and risk from debt. However, continuous losses have eroded equity, which could be a concern if cash burn continues without revenue generation.
Cash Flow
45
Neutral
89bio's operating cash flow is consistently negative, emphasizing the cash outflows related to its operations, typical for biotech firms in the R&D phase. The company has been able to sustain operations through substantial financing activities, shown by positive cash flows from financing. However, the lack of free cash flow generation and increasing cash burn rate pose a future financing risk if no revenue or additional funding is secured.
Breakdown
Dec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income StatementTotal Revenue
0.000.000.000.000.00
Gross Profit
0.00-273.00K-240.00K-79.00K-60.00K
EBIT
-384.66M-151.20M102.25M-89.74M-49.35M
EBITDA
-384.66M-134.46M-99.84M-90.19M-49.50M
Net Income Common Stockholders
-367.08M-142.19M-102.03M-90.12M-49.50M
Balance SheetCash, Cash Equivalents and Short-Term Investments
439.95M578.87M188.16M150.75M204.65M
Total Assets
478.69M596.27M196.82M162.42M211.07M
Total Debt
1.82M27.11M20.05M19.40M0.00
Net Debt
-124.24M-289.05M-35.21M-131.35M-204.65M
Total Liabilities
77.90M59.96M44.99M36.47M8.11M
Stockholders Equity
400.79M536.31M151.83M125.96M202.96M
Cash FlowFree Cash Flow
-367.84M-129.19M-81.10M-76.84M-46.37M
Operating Cash Flow
-367.82M-129.19M-81.09M-76.78M-46.24M
Investing Cash Flow
-40.86M-123.02M-33.94M7.16M-106.83M
Financing Cash Flow
218.59M513.11M117.83M23.87M157.92M

89bio Technical Analysis

Technical Analysis Sentiment
Neutral
Last Price6.55
Price Trends
50DMA
8.20
Negative
100DMA
8.18
Negative
200DMA
8.28
Negative
Market Momentum
MACD
-0.60
Negative
RSI
47.31
Neutral
STOCH
93.71
Negative
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For ETNB, the sentiment is Neutral. The current price of 6.55 is above the 20-day moving average (MA) of 6.50, below the 50-day MA of 8.20, and below the 200-day MA of 8.28, indicating a neutral trend. The MACD of -0.60 indicates Negative momentum. The RSI at 47.31 is Neutral, neither overbought nor oversold. The STOCH value of 93.71 is Negative, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Neutral sentiment for ETNB.

89bio Risk Analysis

89bio disclosed 55 risk factors in its most recent earnings report. 89bio reported the most risks in the “Tech & Innovation” category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

89bio Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
53
Neutral
$857.01M-82.24%-106.10%
VIVIR
51
Neutral
$795.43M-38.09%-13.90%16.56%
51
Neutral
$5.20B3.18-40.80%2.96%17.66%1.94%
46
Neutral
$856.26M-59.77%120.51%25.37%
43
Neutral
$841.19M2.31-42.90%-100.00%94.68%
42
Neutral
$956.20M-78.34%-70.45%
36
Underperform
$880.61M-32.04%12.85%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
ETNB
89bio
6.62
-1.96
-22.84%
SYRE
Spyre Therapeutics
14.22
-18.77
-56.90%
RCUS
Arcus Biosciences
8.09
-7.34
-47.57%
VIR
Vir Biotechnology
5.97
-2.07
-25.75%
ELVN
Enliven Therapeutics
17.97
0.48
2.74%
MLYS
Mineralys Therapeutics, Inc.
13.53
2.17
19.10%

89bio Corporate Events

Product-Related AnnouncementsBusiness Operations and Strategy
89bio Updates on Pegozafermin Clinical Progress
Positive
Apr 9, 2025

On April 9, 2025, 89bio released an updated corporate presentation detailing the progress of their product candidate, pegozafermin, which is currently in late-stage clinical trials for MASH and SHTG. The company highlights pegozafermin’s potential as a best-in-class therapy with a favorable safety profile and robust market opportunities. The presentation outlines the anticipated timelines for clinical trial results and commercialization, emphasizing a strong financial position with significant cash reserves to support ongoing development and operations.

Spark’s Take on ETNB Stock

According to Spark, TipRanks’ AI Analyst, ETNB is a Neutral.

89bio’s stock reflects the high-risk, high-reward nature typical of early-stage biotech companies. The financial performance score is hampered by the lack of revenue and ongoing operational losses, despite a strong cash position. Technical analysis indicates bearish momentum, with potential volatility. The valuation score is low due to negative earnings and no dividend yield, common for firms in the R&D phase. Investors should be mindful of the company’s future reliance on successful R&D outcomes or additional financing.

To see Spark’s full report on ETNB stock, click here.

Glossary
OutperformA stock rated as "Outperform" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests that the stock is likely to deliver higher returns compared to the average returns of other stocks in the same sector or market index. Investors might consider this stock a good buying opportunity.
NeutralA stock rated as "Neutral" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly attractive nor unattractive for investment. Investors may consider holding onto the stock, as it is not expected to either significantly outperform or underperform the market.
UnderperformA stock rated as "Underperform" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests that the stock may deliver lower returns compared to the average returns of other stocks in the same sector or market index. Investors might consider selling the stock or avoiding it as an investment.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.