Competitive PressureBeam Therapeutics will be presenting data at ASH, showing >60% HbF induction in patients, which exceeds the levels reported in Editas's RUBY trial and may exert competitive pressure on reni-cel.
Strategic ShiftEditas Medicine announced a strategic transition to focus entirely on development of in vivo therapies after failing to find a partner for its clinical-stage ex vivo-edited sickle cell/beta thalassemia therapy reni-cel.
Workforce ReductionEditas announced their decision to end the development of reni-cel, an ex vivo gene editor for the treatments of Sickle Cell Disease (SCD) and β-Thalassemia (TDT) after their search for a commercial partner failed, resulting in a ~65% reduction in workforce.