Regulatory ChallengesThe withdrawal of Oxbryta increases the likelihood that regulators will need to see a definitive clinical benefit as a condition for approval, raising the regulatory bar.
Safety ConcernsPrior data from the healthy volunteer trial included cases of treatment-related thrombocytopenia, which remains a concern for the higher doses being tested in the Phase 2b trial.
Stock Valuation ImpactThe POS for the sickle cell opportunity has been adjusted to 20% from 40%, which lowers the price target to $56 from $60.