Clinical Results'179 combined with elebsiran induced significant HBV-specific B and T cell responses, which may be important for immune reactivation.
Immune ResponseParticipants in the combo group who maintained HBsAg loss while off NUC treatment also had higher anti-HBs, suggesting the combo regimen could improve immune reactivation.
Treatment EfficacyNo participant who discontinued NUC treatment required re-treatment, and no HBsAg rebound was observed in those with anti-HBs ≥ 100 IU/L at EOT.