CRDF-004 Trial Progress
The CRDF-004 trial for RAS-mutated mCRC is active in 33 sites, with plans to enroll 90 patients. Enrollment is on track, with initial data readout expected later this year. No new therapies have been approved for this patient population in the past 20 years, and there are no competing trials.
Pancreatic Cancer Program Update
The company is initiating a first-line investigator-initiated PDAC trial combining onvansertib with now [arifox], following the approval of [Nellyrefox] for first-line metastatic PDAC.
Preclinical Success in Ovarian Cancer
Recent preclinical studies show onvansertib's potential in overcoming resistance to PARP inhibitors in ovarian cancer, with promising in vitro and in vivo results.
Strong Financial Position
Cash and short-term investments total $60.3 million as of June 30, 2024, with a cash runway extending through Q3 2025.