Clinical Trial RisksTroriluzole has a checkered history as the drug previously failed in a Ph2/3 SCA study in 2017, failed in a Ph3 trial in generalized anxiety disorder (GAD), failed in a Ph2/3 study in obsessive compulsive disorder (OCD), and failed in a Phase 2/3 study in Alzheimer's disease.
Financial PerformanceMinimal credit is reflected at Biohaven’s current valuation for taldefgrobep alfa, awaiting derisking results in spinal muscular atrophy (SMA) before formally ascribing value to the program.
Regulatory ChallengesThere is uncertainty regarding the FDA's acceptance of the study design for troriluzole, which lacked a placebo group.