Clinical DataTransferrin Receptor-ABC (TfR-ABC) showed sustained strong PK/PD effects up to 2 weeks in non-human primates (NHPs), as well as potential to enable lower peripheral dose needed to enable efficacy.
Pipeline ExpansionThe choice of using GBA1 knockout mice and showing ABC transporter-based enzyme replacement therapy can rescue GCase deficiency, a key enzyme implicated in Parkinson’s disease (PD) and Lewy Body Dementia (LBD), opens exciting possibilities for pipeline expansion down the line.
TechnologyAlector is developing a proprietary versatile blood-brain barrier technology called Alector Brain Carrier (ABC) to enable drug delivery into the CNS at lower, safer efficacious doses.