Data LimitationsThe readout will not include a meaningful look at durability measures like DoR or PFS given the lack of follow-up for patients at higher doses.
Safety And Efficacy ConcernsIn the bear case scenario, there is potential for significant downside if ORR is less than 10% and/or there is an unfavorable safety profile.
Therapy ResistanceResistance will limit re-treatment of ADCs with topoisomerase payloads, highlighting the challenge for existing therapies.