Structure Therapeucs (Nasdaq: GPCR) recently reported Q3 earnings and provided a corporate update. The company outlined the designs for two Phase 2b studies—ACCESS and ACCESS II—that will evaluate GSBR-1290, its oral small molecule GLP-1R agonist, across dose ranges of 45, 90, and 120 mg in 240 mg in ACCESS II. Adopng a "start low and go slow" approach, the dosing regimen begins at 5 mg with 4-week traon intervals, which is expected to reduce GI-related adverse events. GSBR-1290 is poised to become the second oral GLP-1R agonist on the market, and the comprehensive design of these Phase 2b studies is intended to establish a differenated profile for the drug by providing a comprehensive data set. The first paent has been dosed in the ACCESS study, with inial dosing in ACCESS II ancipated by year-end. Topline data from both studies are expected in Q4 2025.