Market CompetitionPotential approvals for Xolair biosimilars, Dupixent, and remibrutinib will likely confine barzo exclusively to 2L+, which is a smaller opportunity than projected.
Patient ComplianceHigh discontinuation rates suggest lower patient compliance and effective drug price.
Safety ConcernsBarzo’s on-target neutropenia, hair discoloration, and other side effects could affect utilization by many patients/clinicians.