Advancement of COM701
Data presented in 2024 showed that COM701, in combination with COM902 and pembrolizumab, resulted in encouraging durable responses in platinum-resistant ovarian cancer patients. The company plans to advance COM701 as a maintenance treatment for platinum-sensitive ovarian cancer, with a strategic trial set to start in Q2 2025.
Strategic Partnerships with AstraZeneca and Gilead
Compugen's collaboration with AstraZeneca for rilvegostomig (derived from COM902) includes seven Phase III trials, with potential milestone payments and royalties. Gilead licensed GS-0321, leading to a $30 million milestone payment in 2024 and the initiation of a Phase I trial.
Strong Financial Position
Compugen reported a cash balance of $103.3 million as of December 31, 2024, with a cash runway expected to last into 2027, supporting the company's operating plans and strategic initiatives.
Promising Results for GS-0321
Received FDA IND clearance and initiated a Phase I trial for GS-0321, an anti-IL-18 binding protein antibody, marking progress in their therapeutic pipeline.