Progress in TSHA-102 Clinical Development
Significant progress was made in the TSHA-102 program for Rett syndrome, including regulatory milestones, clinical data supporting safety, and continued enrollment in high-dose cohorts.
Regulatory Advancements with FDA
Completed Type B meetings with FDA, gaining approval for the pivotal TSHA-102 product use in trials and aligning on a regulatory pathway using the RMAT mechanism.
Encouraging Safety Profile
High-dose TSHA-102 continued to show a favorable safety profile with no serious adverse events reported in both adolescent/adult and pediatric trials.
Financial Stability
Taysha reported cash and cash equivalents of $157.7 million, expected to support operations into the fourth quarter of 2026.
Reduction in Net Loss
Net loss for Q3 2024 was $25.5 million, a significant reduction from $117.1 million in Q3 2023, primarily due to non-cash adjustments.