Promising Data for HIF-2 Alpha Inhibitor
The ARC-20 study showed a 34% ORR and 25% confirmed ORR in the 100-mg cohort, with significant potential for further improvement. The median PFS has not been reached, suggesting strong efficacy in heavily pretreated patients.
Dom-Zim Combination Shows Strong Results
ARC-10 data showed a hazard ratio below 0.65 for both PFS and OS, with a median OS not reached with dom-zim in first-line PD-L1 high non-small cell lung cancer, outperforming contemporary benchmarks.
Financial Position and Collaborations
Arcus Biosciences has $1.1 billion in cash and investments, with a runway into mid-2027, bolstered by collaboration payments from Gilead and Taiho.
Phase 3 Trials and Development Plans
Multiple Phase 3 trials, including PEAK-1 and STAR-221, are underway, targeting significant market opportunities across various cancer indications.